Holding device configured to support a plurality of medical containers such as syringes

ABSTRACT

This holding device comprising a supporting plate, the supporting plate having an upper face, a lower face opposite the upper face, a plurality of openings arranged according to a predetermined pattern and each configured to receive a barrel of one of the medical containers, plurality of reinforcing ribs protruding from at least one of the upper and lower faces and extending between adjacent openings of the plurality of openings, and the plurality of reinforcing ribs comprises at least one oblique rib extending obliquely relative to a longitudinal direction of the supporting plate from one side to another side of the supporting plate and between two different pairs of adjacent peripheral openings.

CROSS-REFERENCE TO RELATED APPLICATIONS

This application is continuation of U.S. patent application Ser. No.17/051,882 filed Oct. 30, 2020, which is the United States nationalphase of International Application No. PCT/EP2019/060511 filed Apr. 24,2019, and claims priority to European Patent Application No. 18305548.2filed May 2, 2018, the disclosures of which are hereby incorporated byreference in their entirety.

BACKGROUND OF THE INVENTION

The present invention relates to a holding device for supporting aplurality of medical containers.

In this application, the distal end of a component or of a device is tobe understood as meaning the end furthest from the user's hand and theproximal end is to be understood as meaning the end closest to theuser's hand. Likewise, in this application, the “distal direction” is tobe understood as meaning the direction of injection, with respect to acontainer supported by the holding device of the invention, and the“proximal direction” is to be understood as meaning the oppositedirection to said direction of injection, that is to say the directiontowards the user's hand holding a container as for an injectionoperation.

Medical containers, such as pre-fillable or prefilled syringes, oftenneed to be transported from one site to another site, for instance froma manufacturing site to a second site where the medical containers maybe filled with a pharmaceutical composition agent, such as a vaccine, amedicine or a therapeutic agent. Less frequently, the medical containersmay be manufactured and filled in the same first site and then betransported to a storage site. During transportation, the medicalcontainers are usually held by a holding device such as a nest.

A nest is a plate-shaped tray that is generally configured to supportmore than one hundred medical containers. The nest comprises severalthrough-holes aligned according to predetermined rows, each hole beingconfigured to receive one medical container. The barrel of each medicalcontainers extends through the holes in a direction substantiallyorthogonal to the nest.

The nest is usually placed inside a box-shaped tub which has one openingsealed by a sealing cover. Removal of the medical containers from thistub basically requires peeling off the sealing cover, removing the nestholding the medical containers from the tub and then removing themedical containers from the nest by axially sliding the medicalcontainers relative to the nest. Before being removed from the nest andpackaged individually, the medical containers are filled with apharmaceutical composition agent by means of a filling machine.

When handled by the filling machines, it may happen that the nestsslightly deform, for example bend or warp, due to the weight of all themedical containers held by the nest. As a result, the flanges of themedical containers supported by the slightly deformed are no morepositioned in a rigorously same plane, which may lead to some inaccuracyduring the filling process.

Besides, even though the existing nests are enabled to concurrentlysupport and handle a large number of medical containers, which limitsthe storage or transportation costs, there however remains a constantneed to reduce costs.

SUMMARY OF THE INVENTION

An aspect of the invention is a holding device configured to support aplurality of medical containers, said holding device comprising: asupporting plate, said supporting structure having an upper face, alower face opposite said upper face, a plurality of openings arrangedaccording to a predetermined pattern and each configured to receive abarrel of one of said medical containers, a plurality of reinforcingribs protruding from at least one of said upper and lower faces andextending between adjacent openings of said plurality of openings.

The holding device according to the invention is therefore stiffened bythe presence of several reinforcing ribs. This increased stiffnessprevents the supporting plate from deforming when this supporting plateis being handled by the filling machines. The accuracy of the fillingprocess may thus be improved. Besides, due to the increased stiffness ofthe holding device, the thickness of the supporting plate may bereduced. As a result, the quantity of raw material necessary tomanufacture the holding device may be reduced, thereby enabling toreduce costs.

The reinforcing ribs of said plurality of reinforcing ribs extend fromone side to another side of the supporting plate.

By a reinforcing rib extending from one side to another side of thesupporting plate it should be understood a reinforcing rib which extendsat least from a row of peripheral openings to another row of peripheralopenings. The peripheral openings are the outermost openings of theplurality of openings; accordingly, the peripheral openings surround theother openings of said plurality of openings. The ends of thereinforcing rib may be located between two different pairs of adjacentperipheral openings. The reinforcing rib may however further extenduntil a peripheral rim of the supporting plate, i.e. from a portion ofsaid peripheral rim to another portion. In this case, the ends of thereinforcing rib are located at the peripheral rim of the supportingplate.

The reinforcing ribs extend between adjacent rows of openings. Thereinforcing ribs are parallel to said adjacent rows of openings. Thereinforcing ribs extend without intersecting the openings.

In an embodiment, the plurality of reinforcing ribs comprises twocentral ribs intersecting each other substantially at the center of thesupporting plate.

In an embodiment, the plurality of reinforcing ribs comprises one orseveral oblique ribs extending obliquely relative to a longitudinaldirection of the supporting plate.

In an embodiment, the plurality of reinforcing ribs comprises primaryreinforcing ribs that are between 1.5 to 2 times thicker than thesupporting plate.

This feature offers the best compromise between cost reduction andstiffness.

The thickness of a reinforcing rib is the distance between two lateralfaces of this reinforcing rib, i.e. the distance measured in a directionorthogonal to a longitudinal direction of the reinforcing rib andparallel to the supporting plate.

The thickness of the supporting plate is the distance between the upperand lower faces of the supporting plate, measured in a directionorthogonal to the supporting plate.

In an embodiment, the plurality of reinforcing ribs comprises at leastone secondary rib extending parallel to one of said central ribs.

In an embodiment, said at least one secondary rib is orthogonal to alongitudinal direction of the supporting plate.

In an embodiment, said at least one secondary rib is thinner than thecentral ribs.

In an embodiment, said at least one secondary rib is thinner than theoblique ribs.

Advantageously, the plurality of reinforcing ribs may include at leastone primary reinforcing rib and at least one secondary reinforcing rib,the at least one secondary reinforcing rib being thinner than the atleast one primary reinforcing ribs.

In an embodiment, at least one central reinforcing rib is between 1.5 to2 times thicker than at least one secondary rib.

In an embodiment, at least one oblique reinforcing rib is between 1.5 to2 times thicker than at least one secondary rib.

Advantageously, the plurality of reinforcing ribs comprises at least onelongitudinal reinforcing rib extending parallel to a longitudinaldirection of the supporting plate. The at least one longitudinalreinforcing rib may be one of the central reinforcing ribs. Theplurality of reinforcing ribs may comprise several longitudinalreinforcing ribs, at least one of them being a primary reinforcing rib.

Advantageously, the plurality of reinforcing ribs comprises at least onetransversal reinforcing rib extending parallel to a transversaldirection of the supporting plate. The at least one transversalreinforcing rib may be one of the central reinforcing ribs. Theplurality of reinforcing ribs may comprise several transversalreinforcing ribs, at least one of them being a primary reinforcing rib.

In an embodiment, each opening is surrounded by a chimney protrudingfrom one of the upper or lower faces of the supporting plate so as toguide insertion of a barrel of the medical containers into said opening.

This feature allows to guide the medical containers through thesupporting plate.

According to one embodiment, the chimney comprises at least two guidingtabs, a slit being delimited between said at least two guiding tabs.

This feature allows to reduce raw material costs due to the slitsbetween the guiding tabs.

According to one embodiment, the chimney comprises four guiding tabs, aslit being delimited between two adjacent guiding tabs.

In an embodiment, said plurality of reinforcing ribs comprises one orseveral reinforcing ribs formed by adjacent chimneys, more preciselyadjacent guiding tabs, connected to each other.

This has the advantage of further reducing raw material costs whilestill improving the stiffness of the supporting plate.

In an embodiment, the chimneys or the guiding tabs forming said one orseveral reinforcing ribs are thicker than the other chimneys or guidingtabs.

Advantageously, the guiding tabs and the reinforcing ribs protrude fromthe same face of the supporting plate.

In an embodiment, the height of the chimney or guiding tabs ispreferably equal to the height of the reinforcing ribs.

The height of a chimney or a guiding tab is the distance between aproximal end and a distal end of the chimney or guiding tab.

In an embodiment, the supporting plate comprises a peripheral edgeprotruding from one of said upper and lower faces and surrounding saidplurality of openings.

This improves the stiffening of the supporting plate.

In an embodiment, at least one of the reinforcing ribs has chamferedends.

This allows reducing the raw material costs without compromising thestiffness of the supporting plate.

In an embodiment, the oblique ribs have chamfered ends.

Advantageously, the openings are arranged in staggered rows.

As a result, the openings of two adjacent rows are offset relative toeach other. Having openings in quincunx relative to each other permitsto support a large number of medical containers. More precisely, anopening is positioned at the center of a square formed by four adjacentopenings.

Advantageously, the holding device is a nest.

A second aspect of the invention concerns an assembly configured tosupport a plurality of medical containers, the assembly comprising: atub; at least one holding device according to the first aspect.

The tub may be a box-shaped housing delimiting an internal volumeconfigured to contain the holding device and the medical containerssupported by this holding device. The tub may have at least one openingconfigured to permit insertion of the holding device into the internalvolume or removal of the holding device outside the tub. The tub mayalso comprise a sealing cover configured to seal the opening and whichmay be peeled off before removal of the holding device. The sealingcover may comprise a Tyvek® sheet or any material that is airtight butpermeable to a sterilization gas such as for example ethylene oxide(EO).

Another aspect is a holding device configured to support a plurality ofmedical containers, said holding device comprising: a supporting plate,said supporting plate having an upper face, a lower face opposite saidupper face, a plurality of openings arranged according to apredetermined pattern and each configured to receive a barrel of one ofsaid medical containers, each opening being surrounded by at least twoguiding tabs protruding from one of the upper or lower faces of thesupporting plate so as to guide insertion of a barrel of the medicalcontainers into said opening, a slit being delimited between said atleast two guiding tabs.

This holding device provides a guiding of the medical containers whenthe medical containers are inserted or removed from the supportingplate, while reducing costs because the slits separating the guidingtabs enable to use as little raw material as possible.

This holding device may also comprise some or all of the additionalfeatures detailed in the present description.

For example, this holding device may comprise a plurality of reinforcingribs protruding from at least one of said upper and lower faces andextending from one to another side of the supporting plate betweenadjacent openings of said plurality of openings.

The plurality of reinforcing ribs may comprise two central ribsintersecting each other substantially at the center of the supportingplate, and oblique ribs extending obliquely relative to said centralribs. The central and oblique reinforcing ribs may be between 1.5 to 2times thicker than the supporting plate.

For example, said plurality of reinforcing ribs comprises one or severalreinforcing ribs formed by adjacent guiding tabs connected to eachother. The guiding tabs forming said one or several reinforcing ribs maybe thicker than the other guiding tabs. The guiding tabs and thereinforcing ribs preferably protrude from the same face of thesupporting plate. The height of the guiding tabs may be equal to orgreater than the height of the reinforcing ribs.

The plurality of reinforcing ribs advantageously comprises at least onesecondary rib extending parallel to one of said central ribs.Preferably, said at least one secondary rib is orthogonal to alongitudinal direction of the supporting plate. Said at least onesecondary rib is advantageously thinner than the central and obliqueribs. Advantageously, the central and oblique reinforcing ribs arebetween 1.5 to 2 times thicker than said at least one secondary rib.Advantageously, said at least one secondary rib and the supporting platemay have a similar thickness. The reinforcing ribs preferably havechamfered ends

For example, the supporting plate comprises a peripheral edge protrudingfrom one of said upper and lower faces and surrounding said plurality ofopenings.

For example, the openings are arranged in staggered rows.

BRIEF DESCRIPTION OF THE DRAWINGS

The invention and the advantages arising therefrom will clearly emergefrom the detailed description that is given below with reference to theappended drawings as follows:

FIG. 1 is a top perspective view of a holding device according to anembodiment of the invention,

FIG. 2 is a bottom perspective view of a holding device according to anembodiment of the invention,

FIG. 3 is a top view of a holding device according to an embodiment ofthe invention, and

FIG. 4 is a bottom view of a holding device according to an embodimentof the invention.

DESCRIPTION OF THE INVENTION

With reference to the figures is shown a holding device 1, or nest,according to an embodiment of the invention. The holding device 1 isconfigured to concurrently support a plurality of medical containers(not shown). The holding device 1 therefore serves as a nest forpackaging, storing, transporting and handling on a filling line themedical containers. A nest is a plate provided with openings eachconfigured to receive one medical containers and having a leaningsurface so that the nest may rest on a shoulder inside a box-shapedhousing or be handled by a filling machine.

It should be noted that the medical containers may be syringes, such aspre-fillable syringes. The medical containers are intended, afterfilling, to contain a pharmaceutical composition such as a vaccine, amedicine or a therapeutic pharmaceutical composition.

A medical container such as a syringe typically comprises an elongatedbarrel defining a reservoir for containing the pharmaceuticalcomposition agent, a plunger stopper located inside the barrel, aplunger to move the plunger stopper inside the barrel and expel thepharmaceutical composition agent through a tip closed by a staked needleand/or needle shield at a distal end of the barrel, and a flange at aproximal end of the barrel. The flange provides a surface forpositioning a user's fingers, generally the index and the middlefingers, while the plunger rod is activated with the thumb.

The holding device 1 comprises a supporting plate 10 configured toconcurrently support the plurality of medical containers. By supportingplate it is meant a substantially plane piece having a small thicknesscompared to the other dimensions such as length and width.

The supporting plate 10 has an upper face 10 a, a lower face 10 bopposite the upper face 10 a and a peripheral rim joining the upper andlower faces 10 a, 10 b.

The supporting plate 10 is preferably rectangular and thus defines twolongitudinal sides 12 a and two transversal sides 12 b.

With reference to FIG. 1 , the supporting plate 10 substantially extendsin a plane XY that is orthogonal to a vertical direction Z. Thelongitudinal sides 12 a extend along a longitudinal direction Xorthogonal to the vertical direction Z and the transversal sides 12 bextend along a transverse direction Y orthogonal to the longitudinal andvertical directions X, Z.

With reference to FIGS. 2 and 4 , the supporting plate 10 may compriseone or several leaning surfaces 13 configured to abut on a shoulderarranged inside a box-shaped housing. These leaning surfaces 13 alsodefine handling portions of the supporting plate 10 so that thesupporting plate 10 may be handled on the filling lines. The leaningsurfaces 13 preferably extend on the lower face 10 b. The leaningsurfaces 13 also preferably extend in the transverse direction Y.

The holding device 1 also comprises a plurality of openings 20, each ofsaid openings 20 being configured to receive the barrel of one of themedical containers. The openings 20 are preferably circular so as toreceive cylindrical barrels. As visible on FIGS. 3 and 4 , the openings20 are through-openings which extend through the plate-shaped structure10 from the upper face 10 a to the lower face 10 b.

The openings 20 are arranged according to a predetermined pattern suchas parallel rows which for example may be seen as extending along thelongitudinal direction X or the transverse direction Y or an obliquedirection with regard to the longitudinal and transverse directions X,Y. As illustrated on the Figures, the openings 20 may be arranged instaggered rows, that is to say in quincux, so that the holding device 1may receive as much medical containers as possible.

The supporting plate 10 may comprise abutment surfaces 14 eachconfigured to support the flange of one of the medical containers. Eachabutment surface 14 preferably extends around one of the openings 20,and may be part of the upper or lower face 10 a, 10 b, preferably theupper face 10 a as visible on FIG. 1 , or which may be located at thedistal end 40 b of a chimney 40. The abutment surfaces 14 may have acircular shape.

With reference to FIGS. 2 and 4 , the holding device 1 may comprise aplurality of reinforcing ribs 30 configured to stiffen the supportingplate 10. The reinforcing ribs 30 protrude from one of the upper orlower face 10 a, 10 b, preferably the lower face 10 b, andlongitudinally extend between adjacent openings 20.

The reinforcing ribs 30 extend between two adjacent longitudinal,transversal or oblique rows of openings 20. The reinforcing ribs 30 areparallel to said adjacent rows of openings 20. The reinforcing ribs 30extend without intersecting the openings 20.

The reinforcing ribs 30 may be shaped as walls protruding orthogonallyto the supporting plate 10. As shown on FIGS. 2 and 4 , the reinforcingribs 30 longitudinally extend along a direction orthogonal to thevertical direction Z. The reinforcing ribs 30 may be straight, or may bewavy as will be described hereinafter. Anyway, the reinforcing ribs 30longitudinally extend along a substantially straight line.

It should be noted that the reinforcing ribs 30, preferably all thereinforcing ribs 30, extend from one side 12 to another side 12 of thesupporting plate 10. More precisely, the reinforcing ribs 30longitudinally extend at least from one peripheral row 21 to anotherperipheral row 21 of the plurality of openings 20. The peripheral rows21 of openings 20 are formed by the outermost openings 22 of theplurality of openings 20. In the example shown on FIG. 3 , the holdingdevice 1 comprises four peripheral rows 21.

The reinforcing ribs 30 have two opposite ends 33 which are preferablylocated at two different sides 12 of the supporting plate 10. Forexample, each end is located between two adjacent peripheral openings22. It should be noted that the reinforcing ribs 30 extend continuouslyfrom one end to the other. As shown on FIG. 2 , at least somereinforcing ribs 30 advantageously have chamfered ends. As a result, theheight of these reinforcing ribs 30 decreases towards these ends.

As can be seen on FIG. 2 or 4 , the plurality of reinforcing ribs 30 mayinclude primary reinforcing ribs 31 and secondary reinforcing ribs 32,the secondary reinforcing ribs 32 being advantageously thinner than theprimary reinforcing ribs 31.

The holding device 1 may comprise one or several central reinforcingribs 310 a, 310 b. These central reinforcing ribs 310 a, 310 b crosseach other substantially at the center of the supporting plate 10, asvisible on FIG. 4 . The central reinforcing ribs 310 a, 310 b may have awavy shape. Preferably, the central reinforcing ribs 310 a, 310 b areperpendicular to each other.

A first central reinforcing rib 310 a extends from the middle of one ofthe transversal sides 12 b to the middle of the opposite transversalside 12 b, along a direction substantially parallel to the longitudinalsides 12 a of the supporting plate 10.

A second central reinforcing rib 310 b extends from the middle of one ofthe longitudinal sides 12 a to the middle of the opposite longitudinalside 12 a, along a direction substantially parallel to the transversalsides 12 b of the supporting plate 10.

The holding device 1 may also comprise one or several obliquereinforcing ribs 310 c which extend obliquely relative to the centralreinforcing ribs 310 a, 310 b. Preferably, the oblique reinforcing ribs310 c each extends from one of the longitudinal side 12 a to one of thetransversal sides 12 b. Preferably, the oblique reinforcing ribs 310 care straight.

In the example shown of FIGS. 2 and 4 , the holding device 1 comprisesfour oblique reinforcing ribs 310 c. The central reinforcing ribs 310 a,310 b divide the supporting plate in several areas, such as fourquarters. In each of these areas extends one oblique reinforcing ribs310 c.

In the embodiment illustrated on FIGS. 2 and 4 , the oblique reinforcingribs 310 c have chamfered ends.

The central reinforcing ribs 310 a, 310 b and the oblique reinforcingribs 310 c form the primary reinforcing ribs 31. As mentioned above, theholding device 1 may further include at least one secondary reinforcingrib 32, for example two secondary reinforcing ribs 32 as illustrated onFIGS. 2 and 4 . In a embodiment, the secondary reinforcing ribs 32 areadvantageously parallel to one of the central reinforcing ribs 310 a,310 b, for example parallel to the second central reinforcing rib 310 b.Preferably, the secondary reinforcing ribs 32 extend from a longitudinalside 12 a of the supporting plate 10 to the opposite longitudinal side12 a. As a result, the secondary reinforcing ribs 32 increase thestiffness of the supporting plate 10 without requiring too much rawmaterial. The secondary reinforcing ribs 32 may be wavy, such as thecentral reinforcing ribs 310 a, 310 b. The secondary reinforcing ribs 32may be arranged symmetrically relative to one of the to one of thecentral reinforcing ribs 310 a, 310 b, for example parallel to thesecond central reinforcing rib 310 b.

Preferably, the thickness of the main reinforcing ribs 31 is comprisedbetween 150% and 200% of the thickness of the second reinforcing ribs32. The thickness of the reinforcing ribs is measured in a directionorthogonal to their longitudinal direction and parallel to thehorizontal plane XY. It should also be noted that the primaryreinforcing ribs 31 advantageously have a thickness that is between 150%to 200% of the thickness of the supporting plate 10. The thickness ofthe supporting plate 10 is the distance measured in the verticaldirection Z between the upper and lower faces 10 a, 10 b. Stilladvantageously, the secondary reinforcing ribs 32 and the supportingplate 10 may have a similar thickness.

For example, the plate-shaped structure 10 may have a thicknesscomprised between 1.3-1.5 mm, preferably 1.4 mm. The primary reinforcingribs 31 may have a thickness comprised between 2.3-2.6 mm, for example athickness of 2.5 mm for the central reinforcing ribs 310 a, 310 b and athickness of 2.4 mm for the oblique reinforcing ribs 310 c. Thesecondary reinforcing ribs 32 may have a thickness comprised between1.3-1.5 mm, preferably 1.4 mm.

With reference to FIGS. 1 and 2 , the holding device 1 may comprisechimneys 42, formed by guiding tabs 40, which are configured to form aguiding conduit around each opening 20 in order to guide insertion ofthe barrel of the medical containers into each of these openings 20.

The guiding tabs 40 protrude from one of the upper and lower faces 10 a,10 b of the supporting plate 10, preferably from the lower face 10 b.The guiding tabs 40 and the abutment surfaces 14 are arranged onopposite faces of the supporting plate 10.

In a preferred embodiment, the guiding tabs 40 and the reinforcing ribs30 preferably protrude from the same face of the supporting plate 10. Ina preferred embodiment, the guiding tabs 40 protrude orthogonally to thesupporting plate 10, along the vertical direction Z.

The guiding tabs 40 extend around the openings 20 so that each openingis surrounded by at least two guiding tabs 40, for example four such asvisible on FIG. 2 . As shown on FIG. 2 , each guiding tab 40 has aproximal end 40 a which is secured to the supporting structure 10 and adistal end 40 b opposite said proximal end 40 a. The proximal end 40 aextends along the periphery of one of the openings 20. The proximal end40 a and the distal end 40 b may have an arcuate shape so that theguiding tabs 40 have a cylindrical shape.

As visible on FIG. 2 , the guiding tabs 40 of a same opening 20 areseparated by slits 41. The slits 41 may advantageously extend along adirection orthogonal to the supporting plate 10. The slits 41 preferablyextend from the proximal end 40 a to the distal end 40 b of the guidingtabs 40.

In a preferred embodiment, the height of the reinforcing ribs 30 isequal to or lower than the height of the guiding tabs 40.

With reference to FIGS. 2 and 4 , at least some of the reinforcing ribs30, especially those which extend parallelly to the rows of openings 20,such as the central reinforcing ribs 310 a, 310 b, and/or the secondaryreinforcing ribs 32, advantageously integrate one guiding tab 40 of theopenings 20 between which they extend. As a result, one of the guidingtabs 40 of an opening 20 adjacent to a reinforcing rib 30 may be part ofthis reinforcing rib 30. These guiding tabs 40 are connected to eachother so as to form the corresponding reinforcing rib 30. It should benoted that these guiding tabs 40 forming a reinforcing rib 30 arethicker than the other guiding tabs 40.

The supporting plate 10 advantageously comprises a peripheral edgeprotruding from one of said upper and lower faces 10 a, 10 b, forexample from the upper face 10 a, and surrounding the plurality ofopenings 20. The peripheral edge and the reinforcing ribs 30 protrudefrom opposite faces of the supporting plate 10. It should however benoted that the peripheral edge and the reinforcing ribs 30 may protrudefrom the same face of the supporting plate 10. The peripheral edgeadvantageously protrude orthogonally to the supporting plate 10.

The peripheral edge extend preferably continuously, i.e. withoutinterruption, all around the supporting plate 10. As shown on theFigures, the peripheral edge may be running on from the peripheral rim.

Preferably, the holding device 1 is made of a plastic material, such aspolypropylene (PP). The supporting plate 10, the reinforcing ribs 30and/or the guiding tabs 40, and/or the peripheral edge are preferablymolded in a single piece.

What is claimed is:
 1. A holding device configured to support aplurality of medical containers, said holding device comprising: asupporting plate, said supporting plate having an upper face, a lowerface opposite said upper face, a thickness defined between the upper andlower faces, a plurality of openings arranged according to apredetermined pattern and each configured to receive a barrel of one ofthe medical containers; and a plurality of reinforcing ribs protrudingfrom at least one of said upper and lower faces and extending betweenadjacent openings of said plurality of openings, wherein the pluralityof reinforcing ribs comprises at least one oblique rib extendingobliquely relative to a longitudinal direction of the supporting platefrom one side to another side of the supporting plate and between twodifferent pairs of adjacent peripheral openings, wherein the at leastone oblique rib defines a thickness that is between 150% to 200% of thethickness of the supporting plate.
 2. The holding device according toclaim 1, wherein at least one reinforcing rib extends at least from arow of peripheral openings to another row of peripheral openings.
 3. Theholding device according to claim 1, wherein the plurality ofreinforcing ribs comprises two central ribs intersecting each othersubstantially at the center of the supporting plate, thereby dividingthe supporting plate in four quarters.
 4. The holding device accordingto claim 3, wherein the plurality of reinforcing ribs comprises at leastone secondary rib extending parallel to one of said central ribs.
 5. Theholding device according claim 4, wherein said at least one secondaryrib is orthogonal to a longitudinal direction of the supporting plate.6. The holding device according claim 4, wherein said at least onesecondary rib is thinner than the central ribs.
 7. The holding deviceaccording claim 4, wherein said at least one secondary rib is thinnerthan the at least one oblique rib.
 8. The holding device according toclaim 1, wherein the supporting plate comprises a peripheral edgeprotruding from one of said upper and lower faces and surrounding saidplurality of openings.
 9. The holding device according to claim 1,wherein at least one of the reinforcing ribs has chamfered ends.
 10. Theholding device according to claim 1, further comprising, four obliqueribs, each extending in one of four quarters of the supporting plate.11. An assembly configured to support a plurality of medical containers,the assembly comprising: a tub; and at least one holding deviceaccording to claim 1, the at least one holding device being containedinside the tub.
 12. The holding device according to claim 1, wherein thesupporting plate has a thickness between 1.3 mm to 1.5 mm.
 13. Theholding device according to claim 12, wherein the at least one obliquerib has a thickness between 2.3 mm to 2.6 mm.